ADVANCING PATERNAL AND MATERNAL AGE ARE BOTH IMPORTANT FOR AUTISM RISK

Advancing Paternal Age and Risk of Autism

Advancing paternal age and autism.

CONTEXT Maternal and paternal ages are associated with neurodevelopmental disorders. OBJECTIVE To examine the relationship between advancing paternal age at birth of offspring and their risk of autism spectrum disorder (ASD). DESIGN Historical population-based cohort study. SETTING Identification of ASD cases from the Israeli draft board medical registry. PARTICIPANTS We conducted a stu...

Maternal and paternal age and risk of autism spectrum disorders.

OBJECTIVE To explore the association between maternal and paternal age and risk of autism spectrum disorders (ASDs) in offspring. DESIGN Historical birth cohort study. SETTING Kaiser Permanente (KP) in Northern California. PARTICIPANTS All singleton children born at KP from January 1, 1995, to December 31, 1999, were included in the study. We identified 593 children who had ASD diagnoses ...

Autism risk across generations: a population-based study of advancing grandpaternal and paternal age.

IMPORTANCE Advancing paternal age has been linked to autism. OBJECTIVE To further expand knowledge about the association between paternal age and autism by studying the effect of grandfathers' age on childhood autism. DESIGN Population-based, multigenerational, case-control study. SETTING Nationwide multigeneration and patient registers in Sweden. PARTICIPANTS We conducted a study of in...

Paternal age and maternal age are risk factors for miscarriage; results of a multicentre European study.

BACKGROUND It is well known that miscarriage risk increases with age. However, studies usually investigate only maternal age effects. We investigated both maternal age and paternal age effects on miscarriage risk to provide insight into this frequent reproductive failure. METHODS The last planned pregnancies (n = 3174) that ended in a birth or miscarriage were analysed in a retrospective popu...